Tesamorelin
Tesamorelin (10mg) is a research grade, 44-amino acid synthetic analog of human growth hormone-releasing hormone (GHRH 1-44), supplied as a lyophilized powder at ≥99% purity (HPLC verified). This peptide features an N-terminal trans-3-hexenoic acid modification and is widely referenced in peer-reviewed literature investigating the growth hormone axis. For research use only.
Product Description
Tesamorelin — Stabilized GHRH Analog Research Peptide (10mg / 20mg)
Tesamorelin (TH9507) is a stabilized synthetic analog of growth-hormone-releasing hormone (GHRH), one of the most clinically characterized GHRH analogs in the research literature. Its N-terminal trans-3-hexenoyl modification confers resistance to enzymatic degradation, making it a robust tool for studying GHRH-receptor signaling and the somatotropic axis. Available in 10mg and 20mg sizes; select your research format above. Purity ≥98%, verified by HPLC and mass spectrometry.
Research Specifications
| Compound | Tesamorelin (TH9507) |
| CAS Number | 218949-48-5 |
| Molecular Formula | C221H366N72O67S |
| Molecular Weight | 5135.9 g/mol |
| PubChem CID | 16137828 |
| Sequence | Trans-3-hexenoyl-modified GHRH(1-44) analog (44 amino acids) |
| Reported Half-Life | ~26–38 minutes in published pharmacokinetic reports |
| Purity | ≥98% (HPLC / MS verified) |
| Appearance | White lyophilized powder |
| Solubility | Soluble in bacteriostatic or sterile water |
| Form | Lyophilized powder for reconstitution |
Mechanism of Action
Tesamorelin binds the GHRH receptor on pituitary somatotrophs, stimulating endogenous synthesis and pulsatile release of growth hormone (GH) through cAMP/PKA signaling.
Stabilized GHRH Backbone
The trans-3-hexenoyl group at the N-terminus protects tesamorelin from rapid enzymatic breakdown, extending its functional window relative to native GHRH(1-44) in research settings.
Somatotropic-Axis Research
Because it stimulates the body's own GH release rather than supplying exogenous GH, tesamorelin is a valuable tool for studying physiological GH-axis regulation and feedback.
Visceral-Adipose Signaling
Tesamorelin is notable in the literature for research into GH-axis effects on visceral adipose tissue.
Research Applications
GH-Axis Research
Used to study GHRH-receptor signaling and pulsatile GH release in preclinical models.
Metabolic & Adipose Research
Investigated for GH-axis effects on visceral fat metabolism.
Comparative GHRH Pharmacology
Studied alongside GHRH analogs such as CJC-1295 to compare stability and signaling.
Published Research Studies
1. Falutz J, et al. (2007) – tesamorelin research
Published clinical research characterizing tesamorelin's GH-axis and visceral-adipose effects. (PMID: 18184952)
Reconstitution and Handling in Research
The following summarizes standard laboratory handling for lyophilized research peptides. This product is intended for research use only and is not for human consumption.
Reconstitute the lyophilized powder by adding bacteriostatic or sterile water down the inside wall of the vial using a sterile syringe. Gently swirl to dissolve—do not shake, as agitation can shear peptide structure. The solvent volume selected determines the working concentration for a given research protocol. For step-by-step technique and dilution calculations, see our peptide reconstitution guide and pair with bacteriostatic water.
Storage and Handling
Lyophilized (unreconstituted): Store at -20°C for long-term stability (up to 24 months) or at 2–8°C for shorter periods, protected from light and moisture. Avoid repeated freeze-thaw cycles.
Reconstituted: Store at 2–8°C and use within 4–6 weeks. For longer storage, aliquot into single-use volumes and freeze at -20°C. See our full peptide storage guide.
Safety Profile in Research
As with all research compounds, investigators should follow standard laboratory safety protocols, including appropriate personal protective equipment (PPE) when handling reconstituted solutions. Tesamorelin is for in-vitro and laboratory research use only and is not intended for human consumption, therapeutic use, or diagnostic purposes. A downloadable Research Product Safety Sheet is available in the Documentation & Research Resources section on this page.
Frequently Asked Questions
What sizes does Tesamorelin come in?
Tesamorelin is available as a variable product in 10mg and 20mg vials. Use the size selector above to choose your research format.
What is tesamorelin used for in research?
Tesamorelin is used to study GHRH-receptor signaling, the somatotropic axis, and GH-axis metabolic effects in laboratory models. It is intended strictly for research use.
What is the purity of Tesamorelin?
Each batch is verified at ≥98% purity by HPLC and mass spectrometry.
Why Buy Tesamorelin from Iron Peak Peptides?
Every batch of Tesamorelin undergoes third-party analytical testing—HPLC, mass spectrometry, and endotoxin screening—to verify purity, identity, and composition, with batch-specific quality-assurance documentation included. Iron Peak Peptides maintains full traceability from raw material to finished vial, ships quickly with proper handling, and backs every order with responsive research support. When you choose IronPeak, you partner with a supplier that prioritizes scientific rigor and product quality above all else.
References & Research Resources
Additional Information
| Size | 10mg, 20mg |
|---|
