IPP-1 SM 10mg
IPP-1 SM 10mg is a synthetic glucagon-like peptide-1 (GLP-1) receptor agonist researched for its effects on incretin signaling pathways and metabolic regulation in preclinical models. HPLC-verified >=99% purity. For Research Purposes Only. Not for human consumption.
Availability: In stock
Product Description
IPP-1 SM 10mg — GLP-1 Receptor Agonist Research Peptide
IPP-1 SM is a synthetic glucagon-like peptide-1 (GLP-1) receptor agonist, one of the most extensively characterized incretin research peptides. Its acylated, DPP-4-resistant structure supports an extended half-life, making it a benchmark GLP-1 monoagonist tool compound for metabolic-signaling research. Each vial contains 10mg of lyophilized peptide at ≥98% purity, verified by HPLC and mass spectrometry.
Research Specifications
| Compound | IPP-1 SM (NN9535) |
| CAS Number | 910463-68-2 |
| Molecular Formula | C187H291N45O59 |
| Molecular Weight | 4113.6 g/mol |
| PubChem CID | 56843331 |
| Sequence | GLP-1 analog: human GLP-1 backbone with Aib at position 8, Arg34, and C18 di-acid acylation at Lys26 |
| Reported Half-Life | ~7 days (~165 hours) in published pharmacokinetic literature |
| Purity | ≥98% (HPLC / MS verified) |
| Appearance | White lyophilized powder |
| Solubility | Soluble in bacteriostatic or sterile water |
| Form | Lyophilized powder for reconstitution |
Mechanism of Action
IPP-1 SM is an agonist at the GLP-1 receptor, a class B G-protein-coupled receptor. Activation stimulates adenylate cyclase and raises intracellular cyclic AMP (cAMP), driving glucose-dependent insulinotropic signaling in pancreatic beta-cell research models.
GLP-1 Receptor Engagement
As a highly selective GLP-1 monoagonist, IPP-1 SM is the standard reference ligand for studying GLP-1-receptor signaling, receptor internalization, and downstream cAMP responses.
Extended Half-Life Design
The Aib-8 substitution confers resistance to DPP-4 degradation, while the C18 di-acid acylation promotes reversible albumin binding—together underpinning the multi-day half-life used in weekly research protocols.
Comparative Incretin Pharmacology
IPP-1 SM is the canonical comparator against dual and triple agonists such as IPP-2 TRZ and IPP-3 RT.
Research Applications
Incretin & Beta-Cell Research
Used to study glucose-dependent insulin secretion and GLP-1-receptor signaling in cell-culture and animal models.
Energy-Homeostasis Studies
A reference compound for research into central and peripheral energy-balance pathways.
Comparative Receptor Pharmacology
The benchmark GLP-1 monoagonist for comparison against multi-receptor incretin peptides.
Published Research Studies
1. Wilding JPH, et al. (2021) – STEP 1
A landmark clinical study characterizing once-weekly IPP-1 SM's metabolic effects, providing a foundational reference dataset for GLP-1 research. (PMID: 33567185)
Reconstitution and Handling in Research
The following summarizes standard laboratory handling for lyophilized research peptides. This product is intended for research use only and is not for human consumption.
Reconstitute the lyophilized powder by adding bacteriostatic or sterile water down the inside wall of the vial using a sterile syringe. Gently swirl to dissolve—do not shake, as agitation can shear peptide structure. The solvent volume selected determines the working concentration for a given research protocol. For step-by-step technique and dilution calculations, see our peptide reconstitution guide and pair with bacteriostatic water.
Storage and Handling
Lyophilized (unreconstituted): Store at -20°C for long-term stability (up to 24 months) or at 2–8°C for shorter periods, protected from light and moisture. Avoid repeated freeze-thaw cycles.
Reconstituted: Store at 2–8°C and use within 4–6 weeks. For longer storage, aliquot into single-use volumes and freeze at -20°C. See our full peptide storage guide.
Safety Profile in Research
As with all research compounds, investigators should follow standard laboratory safety protocols, including appropriate personal protective equipment (PPE) when handling reconstituted solutions. IPP-1 SM 10mg is for in-vitro and laboratory research use only and is not intended for human consumption, therapeutic use, or diagnostic purposes. A downloadable Research Product Safety Sheet is available in the Documentation & Research Resources section on this page.
Frequently Asked Questions
What is IPP-1 SM used for in research?
IPP-1 SM is used to study GLP-1-receptor signaling, glucose-dependent insulin secretion, and energy homeostasis in laboratory models. It is intended strictly for research use.
How does IPP-1 SM differ from IPP-2 TRZ?
IPP-1 SM is a selective GLP-1 receptor monoagonist, whereas IPP-2 TRZ is a dual GIP/GLP-1 agonist. Researchers use them together to characterize the effect of added receptor targets.
What is the purity of IPP-1 SM 10mg?
Each batch is verified at ≥98% purity by HPLC and mass spectrometry.
Why Buy IPP-1 SM 10mg from Iron Peak Peptides?
Every batch of IPP-1 SM 10mg undergoes third-party analytical testing—HPLC, mass spectrometry, and endotoxin screening—to verify purity, identity, and composition, with batch-specific quality-assurance documentation included. Iron Peak Peptides maintains full traceability from raw material to finished vial, ships quickly with proper handling, and backs every order with responsive research support. When you choose IronPeak, you partner with a supplier that prioritizes scientific rigor and product quality above all else.
