FOXO4-DRI 10mg
Availability: Only 19 left in stock
Product Description
FOXO4-DRI 10mg — Senolytic Research Peptide
FOXO4-DRI is a D-retro-inverso peptide engineered to disrupt the interaction between FOXO4 and p53 in senescent cells. It emerged from landmark senescence research as a proof-of-concept senolytic tool compound and is widely used to study cellular senescence and aging biology in preclinical models. Each vial contains 10mg of lyophilized peptide at ≥98% purity, verified by HPLC and mass spectrometry.
Research Specifications
| Compound | FOXO4-DRI (D-retro-inverso FOXO4 peptide) |
| CAS Number | 2460055-10-9 |
| Molecular Formula | C228H388N86O64 |
| Molecular Weight | 5357.9 g/mol |
| Sequence | D-retro-inverso peptide derived from the FOXO4 p53-interaction domain |
| Reported Half-Life | Research compound; PK not extensively characterized in public literature |
| Purity | ≥98% (HPLC / MS verified) |
| Appearance | White lyophilized powder |
| Solubility | Soluble in bacteriostatic or sterile water |
| Form | Lyophilized powder for reconstitution |
Mechanism of Action
In senescent cells, FOXO4 sequesters p53 in the nucleus, helping maintain viability. FOXO4-DRI is designed to competitively disrupt the FOXO4-p53 interaction, releasing p53 and, in published research, selectively triggering apoptosis in senescent cells while largely sparing healthy cells.
D-Retro-Inverso Design
The peptide uses D-amino acids in reversed sequence (D-retro-inverso), a strategy that increases protease resistance and stability—making FOXO4-DRI a notable example of rational peptide-engineering in senescence research.
Selective Senolytic Model
Its targeting of the FOXO4-p53 axis makes it a canonical tool compound for investigating selective clearance of senescent cells (senolysis).
Research Applications
Cellular Senescence Research
A reference senolytic tool for studying the elimination of senescent cells in cell-culture and animal models.
Aging Biology
Used to investigate the role of senescent-cell burden in tissue aging and function.
p53-Pathway Studies
Enables research into FOXO4-p53 protein-protein interactions and downstream apoptosis signaling.
Published Research Studies
1. Baar MP, et al. (2017) – FOXO4-DRI targets senescent cells
The landmark Cell study introducing FOXO4-DRI and demonstrating selective senolytic activity in preclinical models. (PMID: 28340339)
Reconstitution and Handling in Research
The following summarizes standard laboratory handling for lyophilized research peptides. This product is intended for research use only and is not for human consumption.
Reconstitute the lyophilized powder by adding bacteriostatic or sterile water down the inside wall of the vial using a sterile syringe. Gently swirl to dissolve—do not shake, as agitation can shear peptide structure. The solvent volume selected determines the working concentration for a given research protocol. For step-by-step technique and dilution calculations, see our peptide reconstitution guide and pair with bacteriostatic water.
Storage and Handling
Lyophilized (unreconstituted): Store at -20°C for long-term stability (up to 24 months) or at 2–8°C for shorter periods, protected from light and moisture. Avoid repeated freeze-thaw cycles.
Reconstituted: Store at 2–8°C and use within 4–6 weeks. For longer storage, aliquot into single-use volumes and freeze at -20°C. See our full peptide storage guide.
Safety Profile in Research
As with all research compounds, investigators should follow standard laboratory safety protocols, including appropriate personal protective equipment (PPE) when handling reconstituted solutions. FOXO4-DRI 10mg is for in-vitro and laboratory research use only and is not intended for human consumption, therapeutic use, or diagnostic purposes. A downloadable Research Product Safety Sheet is available in the Documentation & Research Resources section on this page.
Frequently Asked Questions
What is FOXO4-DRI used for in research?
FOXO4-DRI is a senolytic research peptide used to study cellular senescence, aging biology, and the FOXO4-p53 interaction in laboratory models. It is intended strictly for research use.
What does 'DRI' mean?
DRI stands for D-retro-inverso, a peptide-engineering approach using D-amino acids in reversed sequence to improve stability and protease resistance.
What is the purity of FOXO4-DRI 10mg?
Each batch is verified at ≥98% purity by HPLC and mass spectrometry.
Why Buy FOXO4-DRI 10mg from Iron Peak Peptides?
Every batch of FOXO4-DRI 10mg undergoes third-party analytical testing—HPLC, mass spectrometry, and endotoxin screening—to verify purity, identity, and composition, with batch-specific quality-assurance documentation included. Iron Peak Peptides maintains full traceability from raw material to finished vial, ships quickly with proper handling, and backs every order with responsive research support. When you choose IronPeak, you partner with a supplier that prioritizes scientific rigor and product quality above all else.
