CJC-1295 with DAC 5mg
Availability: In stock
Product Description
CJC-1295 with DAC 5mg — Long-Acting GHRH Analog
CJC-1295 with DAC is a long-acting analog of growth-hormone-releasing hormone (GHRH). Its Drug Affinity Complex (DAC) enables covalent binding to serum albumin, dramatically extending half-life relative to the no-DAC version. This makes it a distinct research tool for studying sustained GHRH-receptor signaling. Note: this is a different compound from CJC-1295 without DAC — the DAC moiety fundamentally changes its pharmacokinetics. Each vial contains 5mg of lyophilized peptide at ≥98% purity, verified by HPLC and mass spectrometry.
Research Specifications
| Compound | CJC-1295 with DAC (DAC:GRF) |
| CAS Number | 446262-90-4 |
| Molecular Formula | C165H269N47O46 |
| Molecular Weight | 3647.2 g/mol |
| PubChem CID | 90479916 |
| Sequence | Modified GRF(1-29) analog bearing a Drug Affinity Complex (DAC) maleimidoproprionyl-lysine moiety |
| Reported Half-Life | Extended (~6–8 days) via albumin binding in published reports |
| Purity | ≥98% (HPLC / MS verified) |
| Appearance | White lyophilized powder |
| Solubility | Soluble in bacteriostatic or sterile water |
| Form | Lyophilized powder for reconstitution |
Mechanism of Action
CJC-1295 with DAC binds and activates the GHRH receptor on pituitary somatotrophs, stimulating GH synthesis and release through cAMP/PKA signaling. Its modified GRF(1-29) backbone confers resistance to DPP-4 degradation.
Drug Affinity Complex (DAC)
The defining feature is the DAC moiety, which forms a covalent bond with circulating serum albumin. This bioconjugation extends plasma half-life to several days in published research, sustaining GHRH-receptor exposure far longer than the no-DAC analog.
Distinct from No-DAC CJC-1295
Researchers use CJC-1295 with DAC specifically when a long-duration GHRH stimulus is required, contrasting it with the short-acting CJC-1295 (no DAC) to study duration-dependent signaling.
Research Applications
Sustained GHRH-Signaling Research
Used to model prolonged GHRH-receptor activation and its effects on the somatotropic axis.
Bioconjugation & Half-Life Studies
The DAC albumin-binding strategy makes it a reference tool for peptide half-life-extension research.
Comparative GHRH Pharmacology
Studied alongside no-DAC CJC-1295 and secretagogues such as ipamorelin to characterize duration and synergy.
Published Research Studies
1. Teichman SL, et al. (2006) – CJC-1295 pharmacokinetics
Characterized the prolonged GH and IGF-1 response to the albumin-binding GHRH analog CJC-1295 in published clinical research. (PMID: 16352683)
Reconstitution and Handling in Research
The following summarizes standard laboratory handling for lyophilized research peptides. This product is intended for research use only and is not for human consumption.
Gently swirl to dissolve—do not shake, as agitation can shear peptide structure. The solvent volume selected determines the working concentration for a given research protocol.
Storage and Handling
Lyophilized (unreconstituted): Store at -20°C for long-term stability (up to 24 months) or at 2–8°C for shorter periods, protected from light and moisture. Avoid repeated freeze-thaw cycles.
Reconstituted: Store at 2–8°C and use within 4–6 weeks. For longer storage, aliquot into single-use volumes and freeze at -20°C. See our full peptide storage guide.
Safety Profile in Research
As with all research compounds, investigators should follow standard laboratory safety protocols, including appropriate personal protective equipment (PPE) when handling reconstituted solutions. CJC-1295 with DAC 5mg is for in-vitro and laboratory research use only and is not intended for human consumption, therapeutic use, or diagnostic purposes. A downloadable Research Product Safety Sheet is available in the Documentation & Research Resources section on this page.
Frequently Asked Questions
How is CJC-1295 with DAC different from the no-DAC version?
The DAC moiety binds serum albumin, extending half-life to several days, whereas no-DAC CJC-1295 is short-acting. They are chemically distinct compounds used for different research durations.
What is CJC-1295 with DAC used for in research?
It is used to study sustained GHRH-receptor signaling, albumin-binding half-life extension, and the somatotropic axis in laboratory models. It is intended strictly for research use.
What is the purity of CJC-1295 with DAC 5mg?
Each batch is verified at ≥98% purity by HPLC and mass spectrometry.
Why Buy CJC-1295 with DAC 5mg from Iron Peak Peptides?
Every batch of CJC-1295 with DAC 5mg undergoes third-party analytical testing—HPLC, mass spectrometry, and endotoxin screening—to verify purity, identity, and composition, with batch-specific quality-assurance documentation included. Iron Peak Peptides maintains full traceability from raw material to finished vial, ships quickly with proper handling, and backs every order with responsive research support. When you choose IronPeak, you partner with a supplier that prioritizes scientific rigor and product quality above all else.
