5-amino-1MQ 10mg
Availability: In stock
Product Description
5-Amino-1MQ 10mg — NNMT Inhibitor Research Compound
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme central to nicotinamide and NAD+ metabolism. It is a research tool for studying NNMT's role in cellular metabolism and adipocyte energy balance. Each vial contains 10mg of research compound at ≥98% purity, verified by HPLC.
Research Specifications
| Compound | 5-Amino-1-methylquinolinium (NNMT inhibitor) |
| CAS Number | 42464-96-0 |
| Molecular Formula | C10H11IN2 |
| Molecular Weight | 286.11 g/mol |
| Reported Half-Life | Research compound; PK characterized in preclinical literature |
| Purity | ≥98% (HPLC verified) |
| Appearance | Yellow to off-white crystalline solid |
| Solubility | Soluble in water and DMSO |
| Form | Powder (research chemical) |
Mechanism of Action
5-Amino-1MQ is a cell-permeable small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT methylates nicotinamide, consuming methyl donors and influencing the cellular pool of nicotinamide available for NAD+ salvage.
NNMT Inhibition
By inhibiting NNMT, 5-Amino-1MQ is studied for its effects on cellular methylation balance and nicotinamide/NAD+ metabolism in adipocyte and metabolic research models.
Metabolic-Signaling Research
Research links NNMT activity to adipocyte energy expenditure, making 5-Amino-1MQ a tool for investigating metabolic-regulation pathways alongside NAD+ precursors such as NAD+.
Research Applications
NNMT Enzyme Research
A reference inhibitor for studying nicotinamide N-methyltransferase activity.
Metabolic & Adipocyte Research
Used to investigate NNMT's role in cellular energy metabolism.
NAD+ Pathway Studies
Studied in the context of nicotinamide salvage and NAD+ biology.
Published Research Studies
1. Neelakantan H, et al. (2018) – small-molecule NNMT inhibition
Characterized 5-amino-1MQ as a small-molecule NNMT inhibitor and its metabolic effects in preclinical models. (PMID: 29175558)
Preparation and Handling in Research
The following summarizes standard laboratory handling for a small-molecule research compound. This product is intended for research use only and is not for human consumption.
This compound has limited aqueous solubility. For in-vitro work, stock solutions are typically prepared in DMSO and then diluted into aqueous buffer immediately before use, taking care not to exceed the solubility limit at the working dilution. Prepare fresh working solutions and protect from light.
Storage and Handling
Lyophilized (unreconstituted): Store at -20°C for long-term stability (up to 24 months) or at 2–8°C for shorter periods, protected from light and moisture. Avoid repeated freeze-thaw cycles.
Reconstituted: Store at 2–8°C and use within 4–6 weeks. For longer storage, aliquot into single-use volumes and freeze at -20°C. See our full peptide storage guide.
Safety Profile in Research
As with all research compounds, investigators should follow standard laboratory safety protocols, including appropriate personal protective equipment (PPE) when handling reconstituted solutions. 5-amino-1MQ 10mg is for in-vitro and laboratory research use only and is not intended for human consumption, therapeutic use, or diagnostic purposes. A downloadable Research Product Safety Sheet is available in the Documentation & Research Resources section on this page.
Frequently Asked Questions
What is 5-Amino-1MQ used for in research?
5-Amino-1MQ is used to study nicotinamide N-methyltransferase (NNMT) inhibition and its role in cellular and adipocyte metabolism. It is intended strictly for research use.
How is 5-Amino-1MQ prepared for in-vitro work?
It is soluble in water and DMSO; stock solutions for in-vitro research are commonly prepared in DMSO and diluted into buffer before use.
What is the purity of 5-Amino-1MQ 10mg?
Each batch is verified at ≥98% purity by HPLC.
Why Buy 5-amino-1MQ 10mg from Iron Peak Peptides?
Every batch of 5-amino-1MQ 10mg undergoes third-party analytical testing—HPLC, mass spectrometry, and endotoxin screening—to verify purity, identity, and composition, with batch-specific quality-assurance documentation included. Iron Peak Peptides maintains full traceability from raw material to finished vial, ships quickly with proper handling, and backs every order with responsive research support. When you choose IronPeak, you partner with a supplier that prioritizes scientific rigor and product quality above all else.
